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The anabolic impact of Eurycoma longifolia has been confirmed in the animal model, when the size and weight of just one muscle was measured in treated and untreated rats of equal size. It was observed that both treatment groups increased the body weight of one muscle by 15 ± 3 grams. According to Dr. John R. McKechnie, Editor-in-Chief, the Journal of Pharmacokinetics and Therapeutics and Chairman of the Scientific Advisory Committee for the American Association of Pharmaceutical Scientists, this "is probably not significant as long as the animals receiving E. longifolia do not become obese." However, he cautioned that the large change in weight was the first indication of a possible benefit. And he added that, as the drug is currently being evaluated at doses of 100,000 mg/day, these effects could "emerge at doses as high as 500,000 mg/day." In the animal study, the authors described the effects of E. longifolia on fat cells, which included increasing the weight of an isolated adipocyte from one body-fat layer. At the highest doses tested at the level of 100 mg twice daily, no change was observed in the volume of fat cells compared with controls. Further studies are currently underway to determine the efficacy and safety of E. longifolia for fat loss and obesity treatment. The authors believe E. longifolia has the potential to represent a new class of orally active and inexpensive therapeutics. Explore further: Aims to block obesity and diabetes with a novel herbal drug More information: Nature Reports, dx.doi.org/10.1038/491437a Similar articles: